PCGF1
protein-coding gene in the species Homo sapiens
Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68, is a RING finger domain protein that in humans is encoded by the PCGF1 gene.
PCGF1 is a component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B, RYBP, BCOR and KDM2B. PCGF1-BCOR assembles via the ubiquitin-like RAWUL domain of PCGF1 and is recruited on the chromatin at KDM2B sites. Within the PRC1-like complex, PCGF1 regulates RING1B ubiquitin ligase activity that catalyzes the ubiquitination of Lys119 on histone H2A, which then leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression.
The public source identifies “PCGF1” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around PCGF1, protein-coding and gene.
Why this record matters
A short description can identify a subject without explaining its stakes. For “PCGF1”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 21, 2026. The linked authority identifier is Q18047761. None of the 0 selected statements returned an explicit reference.
Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.
- Current terminology
- Classification context
- Finding cited technical literature
Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
Three-step research path
- Establish the record: confirm the title “PCGF1”, its source revision and the description used here.
- Expand the search: follow PCGF1 primary sources, PCGF1 archive and PCGF1 research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “PCGF1”?
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- Has classification or technical consensus changed since the cited source?
Search terms from this dossier
This entry incorporates text from “PCGF1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.