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OPA3

protein-coding gene in the species Homo sapiens

Specimen drawers, botanical folios and brass scientific instruments under study light
Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 17, 2025
Entity authorityQ18046643 ↗
Source-derived summary

Optic atrophy 3 protein is a protein that in humans is encoded by the OPA3 gene.

Clinical significance

Costeff syndrome, or 3-methylglutaconic aciduria type III, is a genetic disorder caused by mutations in the OPA3 gene. In addition these mutations disrupt the production of non-shivering heat, as indicated by the dramatic decrease in surface body temperature.

Editorial summary

“OPA3” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what OPA3, protein-coding and gene can confirm, complicate or overturn.

Editorial reviewA sound reference starting point where classification, measurement and the date of the underlying evidence remain visible. The current 56-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its strongest next move is a source search built around OPA3, protein-coding and gene.
Editorial analysis

Why this record matters

“OPA3” is worth following because a concise public description often conceals a longer documentary argument. Here, OPA3, protein-coding and gene provides the most credible route into that argument.

Evidence profile

Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Jul 17, 2025. The linked authority identifier is Q18046643. None of the 0 selected statements returned an explicit reference.

Critical limits

A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “OPA3”, its source revision and the description used here.
  2. Expand the search: follow OPA3 primary sources, OPA3 archive and OPA3 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “OPA3”?
  2. Is the terminology current, historical or disputed?
  3. Has classification or technical consensus changed since the cited source?
Subject index

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Source & attribution

This entry incorporates text from “OPA3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.