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O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJan 23, 2024
Entity authorityQ7072034 ↗
Source-derived summary

In enzymology, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (EC 2.4.1.222) is an enzyme that catalyzes the chemical reaction in which a beta-D-GlcNAc residue is transferred from UDP-D-GlcNAc to the fucose residue of a fucosylated protein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 2J0A​ and PDB: 2J0B​.

References

Stanley P, Irvine KD, Haltiwanger RS, Vogt TF (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 (6794): 369–75.

Editorial summary

This brief starts where responsible research should: with the source description of “O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase” as class of enzymes. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA concise reference frame for defining the subject, testing terminology and identifying the institution closest to the evidence. The current lead gives the account dated anchors—2007, 2000—that can be checked directly. The selected authority fields contribute no independent date. The account is most persuasive where O-fucosylpeptide, 3-beta-N-acetylglucosaminyltransferase and class can be independently traced.
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Why this record matters

The subject matters to the general reference register because the source frames it as class of enzymes. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Jan 23, 2024. The linked authority identifier is Q7072034. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2007 and 2000.

Critical limits

The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Source & attribution

This entry incorporates text from “O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.