Nodaviridae
family of viruses
Nodaviridae is a family of nonenveloped positive-strand RNA viruses. Vertebrates and invertebrates serve as natural hosts. Diseases associated with this family include: viral encephalopathy and retinopathy in fish; covert mortality of shrimp; persistent ocular hypertensive viral anterior uveitis in humans. There are two genera in the family.
History
The name of the family is derived from the Japanese village of Nodamura, Iwate Prefecture where Nodamura virus was first isolated from Culex tritaeniorhynchus mosquitoes.
Virology
Structure
The virus is not enveloped and has an icosahedral capsid (triangulation number = 3) ranging from 29 to 35 nm in diameter. The capsid is constructed of 32 capsomers.
Genome
The genome is linear, positive sense, bipartite (consisting of two segments, RNA1 and RNA2) single stranded RNA comprising 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal.
RNA1, which is ~3.1 kilobases in length, encodes a protein that has multiple functional domains: a mitochondrial targeting domain, a transmembrane domain, an RNA-dependent RNA polymerase (RdRp) domain, a self-interaction domain and an RNA capping domain. In addition, RNA1 encodes a subgenomic RNA3 that encodes protein B2, an RNA silencing inhibitor.
The public source identifies “Nodaviridae” as family of viruses. This brief keeps that definition visible, then builds a research path around Nodaviridae, family and viruses.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Apr 30, 2026. The linked authority identifier is Q3772908. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Nodaviridae” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.