Neuropeptide S receptor
protein-coding gene in the species Homo sapiens
The neuropeptide S receptor (NPSR) is a member of the G-protein coupled receptor superfamily of integral membrane proteins which binds neuropeptide S (NPS). It was formerly an orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Mutations in this gene have also been associated with this disease.
Clinical significance
In the CNS, activation of the NPSR by NPS promotes arousal and anxiolytic-like effects.
In addition, mututations in NPSR have been linked to a susceptibility to asthma (rs3249801, N107I). Hence NPSR has also been called GPRA (G protein-coupled receptor for asthma susceptibility). Activation of NPSR in the airway epithelium has a number of effects including upregulation of matrix metalloproteinases which are involved in the pathogenesis of asthma. It has been shown that activation of NPSR by NPS affects both gastrointestinal motility and mucosal permeability simultaneously.
The public source identifies “Neuropeptide S receptor” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around Neuropeptide, receptor and protein-coding.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Nov 11, 2025. The linked authority identifier is Q18056337. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Neuropeptide S receptor” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.