Chlorzoxazone
chemical compound
Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It can also be administered for acute pain in general and for tension headache (muscle contraction headache). It acts on the spinal cord by depressing reflexes. It is sold under the brand names Lorzone, Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting. In rare cases, chlorzoxazone may cause severe liver dysfunction. Conversely, chlorzoxazone may reduce the liver toxicity of acetaminophen by competitive inhibition.
It is available as a generic medication.
Pharmacology
The mechanism of action of chlorzoxazone is thought to be primarily as an opener of BKCa, SKCa and IKCa calcium-activated potassium channels. General central nervous system depression is the only currently accepted aspect to its medical benefits.
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