CACrown ArchivesThe cinema collection
EN/FR
Search
Menu
Research dossier · Science & Nature

NPTX2

protein-coding gene in the species Homo sapiens

Specimen drawers, botanical folios and brass scientific instruments under study light
Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 17, 2025
Entity authorityQ18030208 ↗
Source-derived summary

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.

Function

This gene encodes a member of the family of neuronal pentraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.

Clinical significance

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Editorial summary

Begin with the source’s own compact description: “NPTX2” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through NPTX2, protein-coding and gene, not as a finished interpretation.

Editorial reviewA practical orientation to terminology and classification, particularly when read beside dated observations, specimens or technical literature. The current 111-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. For this dossier, NPTX2, protein-coding and gene is the immediate research focus.
Editorial analysis

Why this record matters

The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.

Evidence profile

Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Jul 17, 2025. The linked authority identifier is Q18030208. None of the 0 selected statements returned an explicit reference.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “NPTX2”, its source revision and the description used here.
  2. Expand the search: follow NPTX2 primary sources, NPTX2 archive and NPTX2 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “NPTX2”?
  2. Is the terminology current, historical or disputed?
  3. Which observation, specimen, dataset or publication supports the account?
Subject index

Search terms from this dossier

Source & attribution

This entry incorporates text from “NPTX2” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.