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Sodium-hydrogen antiporter 3 regulator 1

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionSep 21, 2026
Entity authorityQ18034036 ↗
Source-derived summary

Sodium-hydrogen antiporter 3 regulator 1 (SLC9A3R1) is a human protein. It is a regulator of Sodium-hydrogen antiporter 3 and is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 (EBP50) or Na+/H+ Exchanger Regulatory Factor (NHERF1). It is believed to interact via long-range allostery, involving significant protein dynamics.

Mechanism

Members of the ezrin (VIL2; MIM 123900)-radixin (RDX; MIM 179410)-moesin (MSN; MIM 309845) (ERM) protein family are highly concentrated in the apical aspect of polarized epithelial cells. These cells are studded with microvilli containing bundles of actin filaments, which must attach to the membrane to assemble and maintain the microvilli. The ERM proteins, together with merlin, the NF2 (MIM 607379) gene product, are thought to be linkers between integral membrane and cytoskeletal proteins, and they bind directly to actin in vitro. Actin cytoskeleton reorganization requires the activation of a sodium/hydrogen exchanger (SLC9A3; MIM 182307). SLC9A3R1 is an ERM-binding protein.[supplied by OMIM]

Interactions

Sodium-hydrogen antiporter 3 regulator 1 has been shown to interact with:

See also

Cystic fibrosis transmembrane conductance regulator

Ezrin

Moesin

Neutron spin echo

Radixin

Solute carrier family

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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“Sodium-hydrogen antiporter 3 regulator 1” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what Sodium-hydrogen, antiporter and regulator can confirm, complicate or overturn.

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This entry incorporates text from “Sodium-hydrogen antiporter 3 regulator 1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.