N. Gautham
Indian crystallographer and bioinformatician
Namasivayam Gautham (born 1955) is a retired Professor Emeritus at the Centre of Advance Study in Crystallography and Biophysics, University of Madras. He is known for his work on DNA Crystallography, protein structure prediction and molecular docking.
Education
In 1975, Gautham obtained his BSc degree in physics from the Madras Christian College, University of Madras. Later, in 1979 he completed his Master of Science degree in physics from Maharaja Sayajirao University of Baroda. He was awarded a PhD in 1983 for research on the Structural biology of isopropylidene nucleoside derivatives under the supervision of Mysore A. Viswamitra.
Career and research
Gautham worked as a Research associate at the Indian Institute of Science. Following his postdoctoral research, he was appointed as a lecturer at the University of Madras in 1985. He was promoted to a full Professor in 1997. He continued to work at the University of Madras until his retirement in 2016.
Gautham used DNA Crystallography to study the impact of metal ions on the transition of right-handed B-DNA to left-handed Z-DNA. as well as the self assembly of DNA decameric sequences into a four-way Holliday junction In the area of structural bioinformatics, Gautham developed a novel Ab initio computational method using Mutually Orthogonal Latin squares (MOLS) - a technique employed in the area of experimental design - to efficiently sample the conformational space of polypeptides and proteins in order to identify global minimum energy conformations.
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