LA-Pip
chemical compound
Lysergic acid piperidide (LA-Pip or LSD-Pip), also known as N-piperidinyllysergamide, is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD). It is the analogue of LSD in which the N,N-diethyl substitution has been replaced with an N-piperidide ring.
The drug has fairly similar affinity and efficacy as a serotonin 5-HT2A receptor agonist compared to LSD, though is variably less potent in terms of EC50Tooltip half-maximal effective concentration depending on the assay. It also has high affinity for the serotonin 5-HT1A and 5-HT2C receptors. LA-Pip has about 8.5% of the antiserotonergic activity of LSD (relative to 2.0% for LSM-775 and 4.7% for LPD-824) in the isolated rat uterus in vitro.
LA-Pip has been said to be non-hallucinogenic or much less psychedelic than LSD in humans. However, this does not appear to have actually been stated anywhere in the originally cited source. Other sources indicate that LA-Pip has not been assessed in humans. Correspondingly, the dose range and potency of LA-Pip as a psychedelic relative to LSD have not been reported.
LA-Pip was first described in the scientific literature by Albert Hofmann and colleagues by 1955.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Feb 12, 2026. The linked authority identifier is Q6459922. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1955.
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This entry incorporates text from “LA-Pip” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.