Sialate O-acetylesterase
class of enzymes
The enzyme sialate O-acetylesterase (EC 3.1.1.53) catalyzes the reaction
N-acetyl-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate
In human it is encoded by the SIAE gene located on chromosome 11.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase.
Function
SIAE activity negatively regulates B lymphocyte antigen receptor signalling and is required for the maintenance of immunological tolerance. It down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance e.g. in mice.
Structure
The SIAE gene contains 15 exons and expresses a protein that is approximately 56 kDa in size. It is known to be expressed in the adult testis.
Clinical Significance
Genetic defects in SIAE have been associated with multiple autoimmune diseases.
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This entry incorporates text from “Sialate O-acetylesterase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.