KMT2A
protein-coding gene in the species Homo sapiens
Histone-lysine-methyltransferase 2A is an enzyme that in humans is encoded by the KMT2A gene. It is a transcriptional coactivator and histone methyltransferase whose SET domain catalyses methylation of lysine 4 on histone H3, a chromatin modification associated with transcriptional activation.
Histone-lysine-methyltransferase 2A regulates cell reproduction. It is active in generating blood cells (hematopoiesis) and during early development. KMT2A rearrangements are known genetic translocations of KMT2A and are a cause of acute leukemias and other cancers. Rearrangements of KMT2A are markers for diagnosis, prognosis, and treatment of acute leukemias. Mutations or dysregulation of the KMT2A protein product are also involved in several other types of cancers as well as developmental abnormalities such as Wiedemann-Steiner syndrome.
This protein belongs to the group of histone-modifying enzymes comprising transactivation domain 9aaTAD and is involved in the epigenetic maintenance of transcriptional memory. Its role as an epigenetic regulator of neuronal function is an ongoing area of research.
Gene
KMT2A gene has 37 exons and resides on chromosome 11 at q23.
“KMT2A” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what KMT2A, protein-coding and gene can confirm, complicate or overturn.
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“KMT2A” is worth following because a concise public description often conceals a longer documentary argument. Here, KMT2A, protein-coding and gene provides the most credible route into that argument.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 9, 2026. The linked authority identifier is Q18029164.
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This entry incorporates text from “KMT2A” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.