Mir-9/mir-79 microRNA precursor family
Precursor microRNA family
The miR-9 microRNA (homologous to miR-79), is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs are processed from hairpin precursor sequences by the Dicer enzyme. The dominant mature miRNA sequence is processed from the 5' arm of the mir-9 precursor, and from the 3' arm of the mir-79 precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. In vertebrates, miR-9 is highly expressed in the brain, and is suggested to regulate neuronal differentiation. A number of specific targets of miR-9 have been proposed, including the transcription factor REST and its partner CoREST.
Species distribution
miR-9 has been identified in Drosophila (MI0000129), mouse (MI0000720[link removed]) and human (MI0000466[link removed]), and the related miR-79 in C. elegans (MI0000050) and Drosophila melanogaster (MI0000374[link removed]).
Role in disease
microRNAs have been implicated in human cancer in a number of studies. It has been shown that human miR-9 expression levels are reduced in many breast cancer samples due to hypermethylation an epigenetic modification. Hildebrandt et al. show that two genes encoding for has-miR-9 are significantly hypermethylated in clear cell renal carcinoma tumours.
“Mir-9/mir-79 microRNA precursor family” enters the record as precursor microRNA family. Crown Archives preserves that source wording while asking what Mir-9, mir-79 and microRNA can confirm, complicate or overturn.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Jul 27, 2026. The linked authority identifier is Q6871961. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Mir-9/mir-79 microRNA precursor family” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.