Median eminence
below the hypothalamus of the brain
The median eminence is generally defined as the portion of the ventral hypothalamus from which the portal vessels arise. The median eminence is a small swelling on the tuber cinereum, posterior to and on top of the pituitary stalk; it lies in the area roughly bounded on its posterolateral region by the cerebral peduncles, and on its anterolateral region by the optic chiasm.
As one of the seven areas of the brain devoid of a blood–brain barrier, the median eminence is a circumventricular organ having permeable capillaries. Its main function is as a gateway for release of hypothalamic hormones, although it does share contiguous perivascular spaces with the adjacent hypothalamic arcuate nucleus, indicating a potential sensory role.
Physiology
The median eminence is a part of the hypothalamus from which regulatory hormones are released. It is integral to the hypophyseal portal system, which connects the hypothalamus with the pituitary gland. The pars nervosa (part of the posterior pituitary gland) is continuous with the median eminence via the infundibular stalk. Parvocellular neurosecretory cells from the hypothalamus terminate in the median eminence.
The median eminence is the structure where secretions of the hypothalamus (releasing and inhibiting hormones) regulatory hormones, known as "hypophysiotropic hormones") collect before entering the portal system emptying into the general circulation. Such hypophysiotropic hormones include: CRF (corticotropin-releasing factor), GnRH (gonadotropin-releasing hormone), TRH (thyrotropin-releasing hormone), GHRH (growth hormone-releasing hormone), and DA (dopamine).
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This entry incorporates text from “Median eminence” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.