Marfan syndrome
genetic disorder of the connective tissue
Marfan syndrome (MFS) is a multisystemic genetic disorder that affects the connective tissue. People with the condition are often tall and thin, with long arms, legs, fingers, and toes. They also typically have exceptionally flexible joints and abnormally curved spines. The most serious complications involve the heart and aorta, with an increased risk of mitral valve prolapse and aortic aneurysm. The lungs, eyes, bones, and the covering of the spinal cord are also commonly affected. The severity of the symptoms is variable.
MFS is caused by a mutation in FBN1, one of the genes that make fibrillin, which results in abnormal connective tissue. It is an autosomal dominant disorder. In about 75% of cases, it is inherited from a parent with the condition, while in about 25%, it is a new mutation. Diagnosis is often based on the Ghent criteria, family history, and genetic testing (DNA analysis).
The public source identifies “Marfan syndrome” as genetic disorder of the connective tissue. This brief keeps that definition visible, then builds a research path around Marfan, syndrome and genetic.
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Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Sep 24, 2026. The linked authority identifier is Q208562. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Marfan syndrome” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.