Simeticone
anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas
Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.
Medical uses
Simethicone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence. While there is a lack of conclusive evidence that simethicone is effective for this use, studies have shown that it can relieve symptoms of functional dyspepsia and functional bloating.
It has not been fully established that simethicone is useful to treat colic in babies, and it is not recommended for this purpose. A study in the United Kingdom reported that according to parental perception simethicone helped infant colic in some cases.
Simethicone can also be used for suspected postoperative abdominal discomfort in infants.
Side effects
Simethicone does not have any known serious or severe side effects. Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.
Though poorly documented, some studies show a possible negative interaction between simethicone and levothyroxine (synthetic T4), meaning it can possibly bind levothyroxine in the GI tract and hence reduce its absorption leaving the patient prone to clinical manifestations of hypothyroidism. It is important to mention the long T1/2 of levothyroxine which makes the phenomenon a matter of at least a week of using levothyroxine with simethicone.
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This entry incorporates text from “Simeticone” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.