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Research dossier · Science & Nature

MACC1, MET transcriptional regulator

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionApr 18, 2026
Entity authorityQ18055664 ↗
Source-derived summary

MACC1, MET transcriptional regulator is a protein that in humans is encoded by the MACC1 gene.

Function

MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Editorial summary

The public source identifies “MACC1, MET transcriptional regulator” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around MACC1, transcriptional and regulator.

Editorial reviewA practical orientation to terminology and classification, particularly when read beside dated observations, specimens or technical literature. The current 84-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its value is orientation rather than verdict, with MACC1, transcriptional and regulator providing the first useful test.
Editorial analysis

Why this record matters

A short description can identify a subject without explaining its stakes. For “MACC1, MET transcriptional regulator”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Apr 18, 2026. The linked authority identifier is Q18055664. None of the 0 selected statements returned an explicit reference.

Critical limits

Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “MACC1, MET transcriptional regulator”, its source revision and the description used here.
  2. Expand the search: follow MACC1, MET transcriptional regulator primary sources, MACC1, MET transcriptional regulator archive and MACC1 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “MACC1, MET transcriptional regulator”?
  2. Has classification or technical consensus changed since the cited source?
  3. Which observation, specimen, dataset or publication supports the account?
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Source & attribution

This entry incorporates text from “MACC1, MET transcriptional regulator” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.