Lysine riboswitch
RNA family
The Lysine riboswitch is a metabolite binding RNA element found within certain messenger RNAs that serve as a precision sensor for the amino acid lysine. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression. Lysine riboswitch are most abundant in Bacillota and Gammaproteobacteria where they are found upstream of a number of genes involved in lysine biosynthesis, transport and catabolism. The lysine riboswitch has also been identified independently and called the L box.
The lysine riboswitch controls metabolic pathways of lysine biosynthesis. In particular the metabolic flux of the tricarboxylic acid (TCA) cycle is effectively controlled by the riboswitch. Controlling metabolic flux is imperative for the development of microorganisms in cell growth, and the use of the lysine riboswitch in its applicable bacterium allows for the use of more effective strategies to accomplish control. It is more effective in comparison to various expensive and difficult methods such as utilizing a gene knockout. With lysine as an intracellular signal, the riboswitch regulates gene expression in response to specific metabolites. The lysine riboswitch was first investigated in Bacilus subtilis, located at the 5'UTR of the lysC gene coding for aspartokinase.
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This entry incorporates text from “Lysine riboswitch” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.