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Lys-MDMA

MDMA prodrug

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionAug 18, 2026
Entity authorityQ131340669 ↗
Source-derived summary

Lys-MDMA, or lysine-MDMA, also known as N-(L-lysinamidyl)-MDMA, is an intended prodrug of MDMA which was being investigated for possible use as a pharmaceutical drug in the treatment of psychiatric disorders. Structurally, lys-MDMA is the amide formed through condensation of MDMA's amine group with the carboxylic acid of lysine; in this way, lys-MDMA is to MDMA as lisdexamfetamine is to dextroamphetamine. As of August 2024, a phase 1 clinical trial comparing MDMA, MDA, lys-MDMA, and lys-MDA has been conducted and completed. Lys-MDMA was being developed by MindMed.

The published phase 1 clinical trial unexpectedly found that lys-MDMA does not convert into MDMA in humans and is completely inactive. This is in contrast to lisdexamfetamine and lys-MDA, which are converted into dextroamphetamine and MDA, respectively.

Editorial summary

“Lys-MDMA” enters the record as mDMA prodrug. Crown Archives preserves that source wording while asking what Lys-MDMA, MDMA and prodrug can confirm, complicate or overturn.

Editorial reviewA concise reference frame for defining the subject, testing terminology and identifying the institution closest to the evidence. The current lead gives the account dated anchors—2024—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Lys-MDMA, MDMA and prodrug.
Editorial analysis

Why this record matters

“Lys-MDMA” is worth following because a concise public description often conceals a longer documentary argument. Here, Lys-MDMA, MDMA and prodrug provides the most credible route into that argument.

Evidence profile

The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Aug 18, 2026. The linked authority identifier is Q131340669. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2024.

Critical limits

The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.

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The closest primary source, responsible institution and strongest cited specialist reference.

Three-step research path

  1. Establish the record: confirm the title “Lys-MDMA”, its source revision and the description used here.
  2. Expand the search: follow Lys-MDMA primary sources, Lys-MDMA archive and Lys-MDMA research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

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Source & attribution

This entry incorporates text from “Lys-MDMA” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.