List of hallucinogens

This is a list of hallucinogens, or psychoactive drugs that produce majorly altered states of consciousness.

Psychedelics

Psychedelics, also known as serotonergic psychedelics or classical hallucinogens, are serotonin 5-HT2A receptor agonists and include the following:

Tryptamines such as psilocybin, psilocin, dimethyltryptamine (DMT), 5-MeO-DMT, bufotenin, and α-methyltryptamine (AMT);

Phenethylamines such as mescaline, DOM, 2C-B, 25I-NBOMe, and MDA;

Lysergamides such as LSD, ergine (LSA), ALD-52 (1A-LSD), ETH-LAD, and LSZ;

Others such as efavirenz, glaucine (possibly), IHCH-7113, mefloquine (possibly), MK-212, quipazine, and RH-34.

Dissociatives

Dissociatives, also known as dissociative hallucinogens or dissociative anesthetics, are NMDA receptor antagonists and include the following:

Arylcyclohexylamines such as ketamine (K), phencyclidine (PCP), methoxetamine (MXE), and tiletamine

Morphinans such as dextromethorphan (DXM), its active metabolite dextrorphan (DXO), and dextrallorphan (DXA)

Adamantanes such as amantadine and memantine

Diarylethylamines such as diphenidine, ephenidine, fluorolintane, and methoxphenidine

Inhalants such as nitrous oxide (N2O) and xenon

Others such as alkyl nitrites (poppers), aptiganel, dexoxadrol, dizocilpine (MK-801 or MK801), etoxadrol, and selfotel

Deliriants

Deliriants are muscarinic acetylcholine receptor antagonists, also known as antimuscarinics or anticholinergics, and include the following:

Tropanes such as atropine, scopolamine (hyoscine), and hyoscyamine

Others such as benztropine, biperidin, dimenhydrinate, diphenhydramine, procyclidine, trihexyphenidyl, and tropicamide

κ-Opioid receptor agonists

κ-Opioid receptor agonists with hallucinogenic effects include the following:

Salvinoids like salvinorin A (found in Salvia divinorum), 2-MMSB, 2-EMSB, and RB-64 (22-thiocyanatosalvinorin A) (possibly)

Benzomorphans such as pentazocine, phenazocine, and alazocine

Morphinans such as levorphanol, levomethorphan, and nalorphine

Others such as spiradoline, enadoline, and HZ-2

GABAergics

GABAA receptor agonists

GABAA receptor agonists with hallucinogenic effects include the following:

Muscimol, one active constituent of Amanita muscaria mushrooms

Gaboxadol (THIP), a synthetic analogue of muscimol

Indirect GABAA receptor agonists

GABAA receptor positive allosteric modulators

Nonbenzodiazepines or Z drugs such as eszopiclone, zaleplon, zolpidem, and zopiclone

GABA reuptake inhibitors

CI-966, a potent GABA transporter 1 (GAT-1) blocker

Oneirogens

Oneirogens, also known as oneirophrenics, have an unknown mechanism of action and include the following:

β-Carbolines and harmala alkaloids such as harmine, harmaline, tetrahydroharmine (THH), 6-methoxyharmalan, and 6-MeO-THH

Iboga alkaloids such as ibogaine and noribogaine

Cannabinoids

Cannabinoids with hallucinogenic effects are cannabinoid CB1 receptor agonists and include the following:

Phytocannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC or simply THC)

Synthetic cannabinoids such as nabilone, JWH-018, JWH-073, and HU-210

Certain monoacylglycerol lipase (MAGL) inhibitors, which inhibit endocannabinoid metabolism and hence are indirect cannabinoid CB1 receptor agonists, also produce partial or full cannabinoid-like discriminative stimulus effects in animal drug discrimination tests. Conversely, fatty acid amide hydrolase (FAAH) inhibitors, which inhibit endocannabinoid inactivation as well, do not substitute for cannabinoids, at least by themselves.