Lysosomal phospholipase A2
protein-coding gene in the species Homo sapiens
Lysosomal phospholipase A2 (LPLA2), also known as Phospholipase A2 group XV, is an enzyme that in humans is encoded by the PLA2G15 gene (previously LYPLA3).
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities.
“Lysosomal phospholipase A2” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what Lysosomal, phospholipase and protein-coding can confirm, complicate or overturn.
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Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Sep 5, 2026. The linked authority identifier is Q18037571. None of the 0 selected statements returned an explicit reference.
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