LSM-775
chemical compound
LSM-775, also known as N-morpholinyllysergamide or as lysergic acid morpholide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).
Use and effects
LSM-775 is less potent than LSD but is reported to have some LSD-like effects at doses ranging from 75 to 1,000 μg orally and a shorter duration. It may only produce weak or threshold psychedelic effects in humans. There have been said to be fewer signs of cardiovascular stimulation and peripheral toxicity with LSM-775 compared to LSD. On the other hand, more recent reports suggest that LSM-75 produces considerable nausea and feelings of lethargy and sedation.
Interactions
Pharmacology
Pharmacodynamics
LSM-775 is a potent full agonist of the serotonin 5-HT1A receptor and a potent partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. It does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. However, LSM-775 can robustly increase head twitches if it is coadministered with the serotonin 5-HT1A receptor antagonist WAY-100635. These findings indicate that serotonin 5-HT1A receptor activation suppresses the psychedelic-like effects of LSM-775.
Chemistry
Synthesis
The chemical synthesis of LSM-775 has been described.
Analogues
Analogues of LSM-775 include the cyclized lysergic acid piperidide (LA-Pip), lysergic acid azepane (LA-Azepane), lysergic acid pyrrolidide (LA-Pyr; LPD-824), lysergic acid pyrrolinide (LPN), and lysergic acid 2,4-dimethylazetidide (LA-Az, LSZ) and the non-cyclized LEO, LA-MeO, ergometrine, and methylergometrine, among others.
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