CD58
mammalian protein found in Homo sapiens
CD58, or lymphocyte function-associated antigen 3 (LFA-3), is a protein that in humans is encoded by the CD58 gene. CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APCs), particularly macrophages, and other tissue cells.
CD58 binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion and recognition between the T cells and Professional Antigen Presenting Cells, facilitating signal transduction necessary for an immune response. This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation, when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis. Genomic region containing the single-nucleotide polymorphism rs1335532, associated with high risk of multiple sclerosis, has enhancer properties and can significantly boost the CD58 promoter activity in lymphoblast cells. The protective (C) rs1335532 allele creates functional binding site for ASCL2 transcription factor, a target of the Wnt signaling pathway.
Structure
The CD58 glycoprotein can be found in two different protein isoforms, each on the cell surface. These include transmembrane and GPI-anchored form. It has been found that in both isoforms, CD58 is able to interact with a variety of different kinases, and is not dependent on only one form.
This brief starts where responsible research should: with the source description of “CD58” as mammalian protein found in Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Sep 13, 2026. The linked authority identifier is Q21113587. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “CD58” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.