KICSTOR subunit 2
protein-coding gene in the species Homo sapiens
KICSTOR subunit 2 is a protein that in humans is encoded by the KICS2 gene (previously C12orf66). The KICSTOR protein is one of four proteins in the KICSTOR protein complex which negatively regulates mechanistic target of rapamycin complex 1 (mTORC1) signaling.
Gene
C12orf66 is located on the minus strand in the locus 12q14.2. C12orf66 variant 1 is 36 Mbp in length spanning the base pairs 64,186,312 - 64,222,296 on chromosome 12. There are 3 total C12orf66 transcript variants. C12orf66 variant 1 is the longest with 4 exons. C12orf66 variant 2 has a shortened exon 1 and is missing exon 4 compared to variant 1. C12orf66 variant 3 is missing exon 4.
Expression
In humans, C12orf66 has higher than average expression in a number of tissues such as endocrine glands as well as lymphoid tissues and cells. Additionally, C12orf66 expression is increased in a number of cancers including leukemia, breast cancer, cervical cancer, and a number of gastrointestinal related cancers.
“KICSTOR subunit 2” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what KICSTOR, subunit and protein-coding can confirm, complicate or overturn.
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“KICSTOR subunit 2” is worth following because a concise public description often conceals a longer documentary argument. Here, KICSTOR, subunit and protein-coding provides the most credible route into that argument.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 3, 2026. The linked authority identifier is Q18051251. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “KICSTOR subunit 2” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.