KIF-binding protein
protein-coding gene in the species Homo sapiens
KIF-binding protein, also known as Kinesin binding protein (KBP), is a protein that in humans is encoded by the KIFBP gene (previously KIAA1279). The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.
Clinical significance
Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).
Interactions
KIAA1279 has been shown to interact with Retinal G protein coupled receptor and Dipeptidase 1.
“KIF-binding protein” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what KIF-binding, protein and protein-coding can confirm, complicate or overturn.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Aug 10, 2026. The linked authority identifier is Q20970074. None of the 0 selected statements returned an explicit reference.
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