Judith Clements
Australian oncologist
Judith Ann Clements is an Australian academic and educator, specializing in Kallikrein proteases in prostate and ovarian cancers. Clements is the scientific director at the Australian Prostate Cancer Research Centre – Queensland and was head of the Cancer Research Program at the Institute of Health and Biomedical Innovation (IHBI) of Queensland University of Technology at the Translational Research Institute (Australia) from 1997 to 2014. Her biography was published in the Cancer and Metastasis Reviews in 2019
Research
The Cancer Research Program led by Clements at QUT-IHBI, aims to more clearly understand the molecular and cellular basis for the development, progression, and metastasis of solid tumours.
Clements has commented on her research, stating:
"The primary interest of my group within the Hormone Dependent Cancer Program is the tissue kallikrein family of serine proteases. Our group was one of three worldwide that identified and characterised the expanded human tissue kallikrein gene locus on chromosome 19q13.4 in 1999. Since that time, our research has focused on defining the roles of particular kallikreins, and their variant forms, in hormone dependent cancers such as prostate, ovarian and endometrial cancer. We have used conventional/real time PCR and immunohistochemistry to determine the association of kallikrein expression with clinical disease to determine their usefulness as biomarkers for detection, prognostic outcome and therapeutic approaches. We are also utilizing over-expression and knockout systems to determine the effect of kallikrein expression in cancer cell lines at the cell biology level. Other studies in progress are directed to understanding the structure/function of the kallikreins, their substrate specificity and in vivo interacting proteins and genomic regulation. Other protease research interests are the type 2 trans membrane serine proteases (with Dr John Hooper) and the ADAMs (with Prof Adrian Herington and Dr Dimitri Odorico).
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