Joro toxin
chemical compound
Joro spider toxin (joro toxin, JSTX) – a toxin which was originally extracted from the venom of the joro spider (Trichonephila clavata), originally native to Japan.
Biochemical analysis
Joro toxin has demonstrated the ability to selectively block
postsynaptic glutamate potentials and
AMPA glutamate receptors.
It inhibits
NMDA receptors in the CNS of vertebrates.
Joro toxin does not affect
aspartate-induced neural depolarization,
resting membrane potential,
nerve terminal spontaneous signalling, or
inhibitory postsynaptic potentials.
Sources
Jackson, Jaewan; Lee, P.N.R. (1988). "Spider toxins as tools for dissecting elements of excitatory amino acid transmission". Trends in Neurosciences. 11 (6): 278–283. doi:10.1016/0166-2236(88)90112-9. PMID 2465627.
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This entry incorporates text from “Joro toxin” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.