Immunoproteomics
study of large set of protein
Immunoproteomics is the study of large sets of proteins (proteomics) involved in the immune response.
Examples of common applications of immunoproteomics include:
The isolation and mass spectrometric identification of MHC (major histocompatibility complex) binding peptides
Purification and identification of protein antigens binding specific antibodies (or other affinity reagents)
Comparative immunoproteomics to identify proteins and pathways modulated by a specific infectious organism, disease or toxin.
The identification of proteins in immunoproteomics is carried out by techniques including gel based, microarray based, and DNA based techniques, with mass spectroscopy typically being the ultimate identification method.
Applications
Immunology
Immunoproteomics is and has been used to increase scientific understanding of both autoimmune disease pathology and progression. Using biochemical techniques, gene and ultimately protein expression can be measured with high fidelity. With this information, the biochemical pathways causing pathology in conditions such as multiple sclerosis and Crohn's disease can potentially be elucidated. Serum antibody identification in particular has proven to be very useful as a diagnostic tool for a number of diseases in modern medicine, in large part due to the relatively high stability of serum antibodies.
Immunoproteomic techniques are additionally used for the isolation of antibodies. By identifying and proceeding to sequence antibodies, scientists are able to identify potential protein targets of said antibodies. In doing so, it is possible to determine the antigen(s) responsible for a particular immune response.
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This entry incorporates text from “Immunoproteomics” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.