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IFT88

protein-coding gene in the species Homo sapiens

Specimen drawers, botanical folios and brass scientific instruments under study light
Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionDec 21, 2025
Entity authorityQ18032734 ↗
Source-derived summary

Intraflagellar transport protein 88 homolog is a protein that is encoded by the IFT88 gene.

Function

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. In 2012 a mutation was found to be responsible for a novel form of ciliopathy and anosmia in humans capable of remedy in mice by adenoviral mediated gene therapy.

Interactions

IFT88 has been shown to interact with BAT2 and WDR62. WDR62 is required for IFT88 localization to the cilia basal body and the cilia axoneme.

Editorial summary

“IFT88” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what IFT88, protein-coding and gene can confirm, complicate or overturn.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current lead gives the account dated anchors—2012—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around IFT88, protein-coding and gene.
Editorial analysis

Why this record matters

“IFT88” is worth following because a concise public description often conceals a longer documentary argument. Here, IFT88, protein-coding and gene provides the most credible route into that argument.

Evidence profile

The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Dec 21, 2025. The linked authority identifier is Q18032734. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2012.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “IFT88”, its source revision and the description used here.
  2. Expand the search: follow IFT88 primary sources, IFT88 archive and IFT88 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “IFT88”?
  2. Which observation, specimen, dataset or publication supports the account?
  3. Has classification or technical consensus changed since the cited source?
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Source & attribution

This entry incorporates text from “IFT88” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.