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Research dossier · Science & Nature

ICA1

gene of the species Homo sapiens

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Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 29, 2025
Entity authorityQ18027475 ↗
Source-derived summary

Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene.

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjögren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Editorial summary

This brief starts where responsible research should: with the source description of “ICA1” as gene of the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA practical orientation to terminology and classification, particularly when read beside dated observations, specimens or technical literature. The current 80-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where ICA1, gene and species can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the science & nature register because the source frames it as gene of the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 29, 2025. The linked authority identifier is Q18027475. None of the 0 selected statements returned an explicit reference.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “ICA1”, its source revision and the description used here.
  2. Expand the search: follow ICA1 primary sources, ICA1 archive and ICA1 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “ICA1”?
  2. Has classification or technical consensus changed since the cited source?
  3. Is the terminology current, historical or disputed?
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Source & attribution

This entry incorporates text from “ICA1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.