Carbidopa/levodopa
combination of carbidopa and levodopa
Carbidopa/levodopa, sold under the brand name Sinemet among others, is a fixed-dose combination used for the treatment of Parkinson's disease. It contains carbidopa, an inhibitor of aromatic amino acid decarboxylation; and levodopa, an aromatic amino acid. It is taken by mouth.
Common side effects include movement problems and nausea. More serious side effects include depression, low blood pressure with standing, sudden onset of sleepiness, psychosis, and increased risk-taking behavior. Carbidopa prevents the breakdown of levodopa outside the brain. In the brain, levodopa is broken down into dopamine – its active form. Carbidopa also helps prevent some of the nausea which levodopa causes.
It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.
“Carbidopa/levodopa” enters the record as combination of carbidopa and levodopa. Crown Archives preserves that source wording while asking what Carbidopa, levodopa and combination can confirm, complicate or overturn.
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This entry incorporates text from “Carbidopa/levodopa” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.