HDAC3
protein-coding gene in the species Homo sapiens
Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.
Function
Histones are alkaline positively charged proteins that package and organize DNA into structural units known as nucleosomes, the primary protein component of chromatin. Posttranslational, enzyme-mediated lysine acetylation and deacetylation of histone tails modify local chromatin structure by altering the electrostatic interaction between the negatively charged DNA backbone and the histones. HDAC3 is a Class I member of the histone deacetylase superfamily, which is divided into four classes based on function and sequence homology. HDAC3 is recruited to enhancers, where it modulates the epigenome and regulates nearby gene expression. It is found exclusively in the cell nucleus, and is the only endogenous histone deacetylase biochemically purified as part of the nuclear receptor corepressor complex containing NCOR and SMRT (NCOR2). Unlike other HDACs, HDAC3 therefore plays a distinct role in regulating the transcriptional activity of nuclear receptors.
Role in intestinal homeostasis
Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors, and bacteria-derived signals. Studies in mice with a specific deletion of HDAC3 in intestinal epithelial cells (IECs) have shown deregulated gene expression in IECs. In these deletion-mutant mice, the loss of Paneth cells, impaired IEC function, and changes in the intestinal composition of commensal bacteria were observed.
“HDAC3” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what HDAC3, protein-coding and gene can confirm, complicate or overturn.
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“HDAC3” is worth following because a concise public description often conceals a longer documentary argument. Here, HDAC3, protein-coding and gene provides the most credible route into that argument.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jul 31, 2026. The linked authority identifier is Q18033475. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “HDAC3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.