HU-210
chemical compound
HU-210 (11-hydroxy-Δ8-THC-1',1'-DMH) is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action. HU-210 has a binding affinity of 0.061 nM at CB1 receptors compared to 40.7 nM for Δ9-THC. The binding pose of HU-210 to the CB1 receptor is similar to other synthetic cannabinoids.
Effects and research
HU-210, the (–) enantiomer, is an ultrapotent cannabinoid, while its (+) enantiomer HU-211 is not a cannabinoid, but an NMDA antagonist with neuroprotective effects.
HU-210 has a TDLO of 25 μg/kg in rats.
Chemistry
HU-210 is the enantiomer of HU-211 (dexanabinol). The original synthesis of HU-210 is based on an acid-catalyzed condensation of (–)-Myrtenol and 1,1-Dimethylheptylresorcinol (3,5-Dihydroxy-1-(1,1-dimethylheptyl)benzol).
Legal status
HU-210 is not listed in the schedules set out by the United Nations' Single Convention on Narcotic Drugs from 1961 nor their Convention on Psychotropic Substances from 1971, so the signatory countries to these international drug control treaties are not required by said treaties to control HU-210.
New Zealand
HU-210 is banned in New Zealand as of 8 May 2014.
United States
HU-210 is not explicitly listed in the list of scheduled controlled substances in the USA. A brief profile of HU-210 written and published by the Drug Enforcement Administration (DEA) in 2009, but removed in later years, stated that HU-210 is a Schedule I controlled substance under the Controlled Substances Act due to being similar to THC. A version of the document (updated in 2013), now in PDF form, exists on the DEA Office of Diversion Control's website.
“HU-210” enters the record as chemical compound. Crown Archives preserves that source wording while asking what HU-210, chemical and compound can confirm, complicate or overturn.
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Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Sep 7, 2026. The linked authority identifier is Q411905. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1988, 1961, 1971 and 2014.
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This entry incorporates text from “HU-210” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.