Zabaglurant
chemical compound
Zabaglurant (INNTooltip International Nonproprietary Name; developmental code names HTL14242 and TMP-301) is a metabotropic glutamate mGlu5 receptor negative allosteric modulator which is under development for the treatment of alcoholism (alcohol use disorder). It is taken orally. The drug was first described in the scientific literature by 2015. It was developed by Sosei Heptares, Nxera Pharma, and Tempero Bio. As of April 2026, the drug is in phase 2 clinical trials for alcoholism. It was also under development for cocaine-related disorders, other substance-related disorders, anxiety disorders, neurological disorders, and psychiatric disorders, but no recent development has been reported or development was discontinued for these indications. In April 2026, a phase 2 trial for alcoholism was terminated due to serious adverse events.
The public source identifies “Zabaglurant” as chemical compound. This brief keeps that definition visible, then builds a research path around Zabaglurant, chemical and compound.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Aug 30, 2026. The linked authority identifier is Q27455393. The first chronological checks are 2015 and 2026.
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This entry incorporates text from “Zabaglurant” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.