HOXA13
protein-coding gene in the species Homo sapiens
Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene.
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
Clinical significance
Expansion of a polyalanine tract in the encoded protein can cause hand-foot-genital syndrome, also known as hand-foot-uterus syndrome. Aberrant expression of HoxA13 gene products in the esophagus, provokes Barrett’s esophagus, a form of metaplasia that is a direct precursor to esophageal cancer.
See also
Homeobox
References
Further reading
External links
GeneReviews/NCBI/NIH/UW entry on Hand-Foot-Genital Syndrome
HOXA13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Begin with the source’s own compact description: “HOXA13” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through HOXA13, protein-coding and gene, not as a finished interpretation.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Nov 13, 2025. The linked authority identifier is Q18027147. None of the 0 selected statements returned an explicit reference.
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