Histone H4 transcription factor
protein-coding gene in the species Homo sapiens
Histone H4 transcription factor (or HiNF-P) is a protein that in humans is encoded by the HINFP gene (previously MIZF). HiNF-P/HINFP stand for "histone nuclear factor P".
Function
HiNF-P is a protein that binds to a highly conserved DNA motif found in most histone H4 genes. HiNF-P activates H4 gene expression through interactions with the CDK2 substrate NPAT which is localized in Histone Locus Bodies. HiNF-P was independently described as a protein called "MBD2 interacting zinc finger protein" (MIZF). MIZF was reported to interact with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex. MIZF is thought to play a role in DNA methylation and transcription repression.[supplied by OMIM]
Interactions
One key partner protein of HiNF-P is NPAT, a CDK2 substrate that localizes to Histone Locus Bodies. HiNF-P has been reported to interact with Methyl-CpG-binding domain protein 2 and DHX9.
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