Pro-hevein
plant protein
Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.
The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.
It has antifungal properties.
Role of hevein in latex allergy
Hevein is the main IgE-binding epitope of the major latex allergen prohevein as are hevein-like protein domains in fruit class I chitinases. Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes. Hevein-like genes can be found in many plants including Arabidopsis thaliana.
Hevein is called Hev b 6 under the WHO allergen nomenclature. There are three entries under this classification, corresponding to the conformational epitopes Hev b 6.01, Hev b 6.03, and Hev b 6.03. They correspond to the full Pro-Havein protein, the matur Hevein (N-terminal), and the C-terminal Barwin domain respectively.
This brief starts where responsible research should: with the source description of “Pro-hevein” as plant protein. Everything that follows is an evidence route, not borrowed authority.
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The subject matters to the science & nature register because the source frames it as plant protein. Its deeper value depends on whether names, dates, institutions and citations support that framing.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 16, 2025. The linked authority identifier is Q7246609. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Pro-hevein” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.