Human anti-mouse antibody
Antibody found in humans
Human anti-mouse antibody or human anti-murine antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice.
The HAMA response
Antibody treatment is a type of therapy that is used to treat certain types of cancer and immune disorders. Antibodies are proteins which are naturally formed by the body in response to a foreign substance, known as an antigen. Antibodies can also be grown outside of the patient’s body and injected into them to help aid the immune system to fight disease. These types of antibodies are typically called monoclonal antibodies because they are created to target one specific antigen. Herceptin and Avastin, two widely used cancer fighting drugs, are examples of monoclonal antibodies.
For several decades, and until recently, mice were used extensively in the production of monoclonal antibodies (MAbs). But the treatments were not as effective as doctors had hoped. One problem was that patients reacted to the mouse antibodies as if they were a foreign substance, and created a new set of antibodies to the mouse antibodies. Doctors have termed this the “HAMA response,” referring to the development of Human Anti-Mouse Antibodies (HAMA).
The public source identifies “Human anti-mouse antibody” as antibody found in humans. This brief keeps that definition visible, then builds a research path around Human, anti-mouse and antibody.
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This entry incorporates text from “Human anti-mouse antibody” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.