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GRB2 associated binding protein 3

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJun 27, 2026
Entity authorityQ18050784 ↗
Source-derived summary

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene.

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Editorial summary

This brief starts where responsible research should: with the source description of “GRB2 associated binding protein 3” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA sound reference starting point where classification, measurement and the date of the underlying evidence remain visible. The current 99-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where GRB2, associated and binding can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jun 27, 2026. The linked authority identifier is Q18050784. None of the 0 selected statements returned an explicit reference.

Critical limits

A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “GRB2 associated binding protein 3”, its source revision and the description used here.
  2. Expand the search: follow GRB2 associated binding protein 3 primary sources, GRB2 associated binding protein 3 archive and GRB2 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “GRB2 associated binding protein 3”?
  2. Has classification or technical consensus changed since the cited source?
  3. Is the terminology current, historical or disputed?
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Source & attribution

This entry incorporates text from “GRB2 associated binding protein 3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.