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Glycoprotein Ib

protein found in platelets

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionMay 17, 2024
Entity authorityQ17110527 ↗
Source-derived summary

Glycoprotein Ib (GPIb), also known as CD42,

is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury. Glycoprotein Ibα (GPIbα) is the major ligand-binding subunit of the GPIb-V-IX complex. GPIbα is heavily glycosylated.

It is deficient in the Bernard–Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand disease.

Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.

Editorial summary

The public source identifies “Glycoprotein Ib” as protein found in platelets. This brief keeps that definition visible, then builds a research path around Glycoprotein, protein and found.

Editorial reviewA dependable orientation record for establishing vocabulary, names and a first evidence trail. The current 76-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its value is orientation rather than verdict, with Glycoprotein, protein and found providing the first useful test.
Editorial analysis

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A short description can identify a subject without explaining its stakes. For “Glycoprotein Ib”, the useful work is to connect “protein found in platelets” to the records capable of establishing context and consequence.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated May 17, 2024. The linked authority identifier is Q17110527. None of the 0 selected statements returned an explicit reference.

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Source & attribution

This entry incorporates text from “Glycoprotein Ib” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.