Mannose-1-phosphate guanylyltransferase
class of enzymes
Mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Arthrobacter combines guanosine triphosphate and mannose 1-phosphate to give guanosine diphosphate galactose, with pyrophosphate (PPi) as a byproduct.
This enzyme is a transferases, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-mannose-1-phosphate guanylyltransferase. Other names in common use include GTP-mannose-1-phosphate guanylyltransferase, PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose, pyrophosphorylase), GDP-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase, guanosine triphosphate-mannose 1-phosphate guanylyltransferase, and mannose 1-phosphate guanylyltransferase (guanosine triphosphate).
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 2CU2.
Begin with the source’s own compact description: “Mannose-1-phosphate guanylyltransferase” is class of enzymes. The dossier treats that line as a proposition to test through Mannose-1-phosphate, guanylyltransferase and class, not as a finished interpretation.
Why this record matters
The phrase “class of enzymes” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.
Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Jul 16, 2026. The linked authority identifier is Q6750938. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2007.
Overview language is designed for orientation and should not be treated as a substitute for the evidence cited beneath it. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “Mannose-1-phosphate guanylyltransferase”, its source revision and the description used here.
- Expand the search: follow Mannose-1-phosphate guanylyltransferase primary sources, Mannose-1-phosphate guanylyltransferase archive and Mannose-1-phosphate research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Mannose-1-phosphate guanylyltransferase”?
- What terminology or title could unlock a more precise catalogue search?
- Which cited source is closest to the event, object or claim?
Search terms from this dossier
This entry incorporates text from “Mannose-1-phosphate guanylyltransferase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.