ADGRG7
protein-coding gene in the species Homo sapiens
Adhesion G protein-coupled receptor G7 is a protein that in humans is encoded by the ADGRG7 gene (previously GPR128). ADGRG7 is a member of the adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Tissue distribution
ADGRG7 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.
Function
Ni et al. showed that Adgrg7 deletion in mice causes reduced body weight and induced intestinal contraction frequency.
Clinical significance
A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and ADGRG7 has been identified in the genome of patients with atypical myeloproliferative neoplasms. Notably, the fused gene was also detected in few healthy individuals.
Begin with the source’s own compact description: “ADGRG7” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through ADGRG7, protein-coding and gene, not as a finished interpretation.
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The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 24, 2026. The linked authority identifier is Q18047828. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “ADGRG7” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.