GLPG1205
chemical compound
GLPG1205 is an experimental drug which acts as a selective antagonist (or perhaps negative allosteric modulator) at the free fatty acid receptor GPR84. It has antiinflammatory and anti-fibrotic effects and reached Phase II human clinical trials for treatment of both ulcerative colitis and idiopathic pulmonary fibrosis, although development for both indications was ultimately dropped due to poor efficacy. However, it continues to be researched for potential applications in the treatment of other conditions such as asthma and acute immune-mediated liver injury.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jul 13, 2026. The linked authority identifier is Q76759113. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “GLPG1205” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.