GFRA1
protein-coding gene in the species Homo sapiens
GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene.
Function
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Interactions
GDNF family receptor alpha 1 has been shown to interact with GDNF and RET proto-oncogene.
The public source identifies “GFRA1” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around GFRA1, protein-coding and gene.
Why this record matters
A short description can identify a subject without explaining its stakes. For “GFRA1”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 15, 2025. The linked authority identifier is Q20970135. None of the 0 selected statements returned an explicit reference.
Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
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Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
Three-step research path
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Questions for further research
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This entry incorporates text from “GFRA1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.