Fumagillin
chemical compound
Fumagillin is a complex biomolecule and used as an antimicrobial agent. It was isolated in 1949 from the microbial organism Aspergillus fumigatus.
Uses
In animals
It was originally used against microsporidian parasites Nosema apis infections in honey bees.
Some studies found it to be effective against some myxozoan parasites, including Myxobolus cerebralis, an important parasite of fish; however, in the more rigorous tests required for U.S. Food and Drug Administration approval, it was ineffective.
There are reports that fumagillin controls Nosema ceranae, which has recently been hypothesized as a possible cause of colony collapse disorder.
The latest report, however, has shown it to be ineffective against N. ceranae.
Fumagillin is also investigated as an inhibitor of malaria parasite growth.
In humans
Fumagillin has been used in the treatment of microsporidiosis. It is also an amebicide.
Fumagillin can block blood vessel formation by binding to an enzyme methionine aminopeptidase 2 and for this reason, the compound, together with semisynthetic derivatives, are investigated as an angiogenesis inhibitor in the treatment of cancer.
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This entry incorporates text from “Fumagillin” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.