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Free fraction

pharmacokinetics parameter

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionMar 4, 2022
Entity authorityQ5500236 ↗
Source-derived summary

The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics.

One speaks of two different free fractions:

Plasma free fraction, previously referred to as ƒ1, is now referred to as ƒP according to consensus nomenclature.

Tissue free fraction (ƒND), previously referred to as ƒ2

The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.

See also

Binding potential

References

Others

Milak MS, Severance AJ, Ogden RT, Prabhakaran J, Kumar JS, Majo VJ, Mann JJ, Parsey RV (2008). "Modeling Considerations for 11C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET". J. Nucl. Med. 49 (4): 587–596. doi:10.2967/jnumed.107.046540. PMC 3580231.

Editorial summary

“Free fraction” enters the record as pharmacokinetics parameter. Crown Archives preserves that source wording while asking what Free, fraction and pharmacokinetics can confirm, complicate or overturn.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current lead gives the account dated anchors—2008—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Free, fraction and pharmacokinetics.
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“Free fraction” is worth following because a concise public description often conceals a longer documentary argument. Here, Free, fraction and pharmacokinetics provides the most credible route into that argument.

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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Mar 4, 2022. The linked authority identifier is Q5500236. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2008.

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Source & attribution

This entry incorporates text from “Free fraction” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.