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Formate—dihydrofolate ligase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 20, 2025
Entity authorityQ5470023 ↗
Source-derived summary

In enzymology, a formate—dihydrofolate ligase (EC 6.3.4.17) is an enzyme that catalyzes the chemical reaction

ATP + formate + dihydrofolate

⇌

{\displaystyle \rightleftharpoons }

ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming).

Editorial summary

This brief starts where responsible research should: with the source description of “Formate—dihydrofolate ligase” as class of enzymes. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA dependable orientation record for establishing vocabulary, names and a first evidence trail. The current 74-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where Formate, dihydrofolate and ligase can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the general reference register because the source frames it as class of enzymes. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Jul 20, 2025. The linked authority identifier is Q5470023. None of the 0 selected statements returned an explicit reference.

Critical limits

The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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  2. Expand the search: follow Formate—dihydrofolate ligase primary sources, Formate—dihydrofolate ligase archive and Formate research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

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Source & attribution

This entry incorporates text from “Formate—dihydrofolate ligase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.