FOXD4L6
protein-coding gene in the species Homo sapiens
Forkhead box D4 like 6 (FOXD4L6) is a protein in Homo sapiens encoded by the FOXD4L6 gene. As a member of the Forkhead box (FOX) transcription factor family it functions as a nuclear DNA-binding transcription factor.
Gene identity
The gene lies within a FOXD4-like cluster and it has several neighboring loci, including FRG1HP, PGM5P2, LINC03025, and ZNG1F.
mRNA transcript
Transcribed as a single-exon gene with no introns; the gene FOXD4L6 produces one major mRNA transcript that is then translated into a chain of 417 amino acids. Because the gene lacks introns, no alternative splicing or isoforms are reported.
Evolution and homology
Gene family context
FOXD4L6 belongs to the Forkhead box (FOX) gene family, an evolutionarily ancient group of transcription factors that originated in unicellular eukaryotes and expanded through multiple duplication events over the last 1.6 to 2.2 billion years.
Unifying feature : the forkhead (FKH) domain
The central FKH domain forms the double winged-helix structure responsible for DNA binding and shows the strongest conservation across vertebrates and invertebrates. In FOXD4L6, the forkhead DNA-binding region falls within the central portion, residue 108 to 202.
Homology
In vertebrates, the family diversified into more than ten subfamilies (FOXA–FOXS). The FOXD sub class includes FOXD1, FOXD2, FOXD3, and the FOXD4/FOXD4-like expansion present in primates. In humans, this expansion produced seven FOXD4L genes, including FOXD4L6.
The public source identifies “FOXD4L6” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around FOXD4L6, protein-coding and gene.
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This entry incorporates text from “FOXD4L6” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.