FOLR3
protein-coding gene in the species Homo sapiens
Folate receptor gamma is a protein that in humans is encoded by the FOLR3 gene. It is involved in up-take of folic acid.
Gene location
The FOLR multi-gene family (FOLR1, FOLR2 and FOLR3) is localized to chromosome 11q13.3–q14.1, and encodes the gene products FRα, β and γ, respectively.
Tissue distribution
FOLR3 is localized in haematopoietic tissue, such as spleen and bone marrow, and is present as a secretory protein. FOLR3 expresses in humans rather than mice and rats.
Function
The FOLR3 gene is polymorphic due to a nonsense mutation resulting in a truncated protein; FRγ, which can bind folic acid. FOLR3 genes each consist of 5 exons, 4 introns and 1 promoter that encodes a single transcript.
Clinical significance
Expression of FOLR3 is correlated more strongly with plasma homocysteine(Hcy) than FOLR1 and FOLR2. FOLR3 may decrease plasma Hcy compared with other FOLRs. It was demonstrated that FOLR3 can metabolize both intracellular Hcy and extracellular Hcy.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 14, 2026. The linked authority identifier is Q17929051. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “FOLR3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.