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Focal proliferative nephritis

medical condition

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionNov 17, 2025
Entity authorityQ5463859 ↗
Source-derived summary

Focal proliferative nephritis is a type of glomerulonephritis seen in 20% to 35% of cases of lupus nephritis, classified as type III. As the name suggests, lesions are seen in less than half of the glomeruli. Typically, one or two foci within an otherwise normal glomerulus show swelling and proliferation of endothelial and mesangial cells, infiltration by neutrophils, and/or fibrinoid deposits with capillary thrombi. Focal glomerulonephritis is usually associated with only mild microscopic hematuria and proteinuria; a transition to a more diffuse form of renal involvement is associated with more severe disease.

Epidemiology

In cases of IgA nephropathy, focal proliferative glomerulonephritis is observed in about 20–50% of renal biopsy specimens. Twenty to sixty percent of patients with lupus who underwent renal biopsies exhibit focal proliferative or mesangial lupus nephritis.

See also

Lupus nephritis

Diffuse proliferative nephritis

References

Further reading

Magil, Alex B.; Ballon, Henry S.; Rae, Angus (1982). "Focal proliferative lupus nephritis". The American Journal of Medicine. 72 (4). Elsevier BV: 620–630.

Editorial summary

This brief starts where responsible research should: with the source description of “Focal proliferative nephritis” as medical condition. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current lead gives the account dated anchors—1982—that can be checked directly. The selected authority fields contribute no independent date. The account is most persuasive where Focal, proliferative and nephritis can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the general reference register because the source frames it as medical condition. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Nov 17, 2025. The linked authority identifier is Q5463859. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1982.

Critical limits

The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.

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The closest primary source, responsible institution and strongest cited specialist reference.

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  1. Establish the record: confirm the title “Focal proliferative nephritis”, its source revision and the description used here.
  2. Expand the search: follow Focal proliferative nephritis primary sources, Focal proliferative nephritis archive and Focal research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

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Source & attribution

This entry incorporates text from “Focal proliferative nephritis” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.